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. 2019 Jul 5;5(7):eaaw4607. doi: 10.1126/sciadv.aaw4607

Fig. 1. Importance of boronic acids, commonly used synthetic methods for the ─B(OH)2 introduction, and our proposed building block–centered approach.

Fig. 1

(A) Marketed drugs containing free ─B(OH)2 moieties. (B) Common methods for late-stage introduction of the ─B(OH)2 moiety. THF-DMF, tetrahydrofuran-dimethylformamide. (C) Building block approach to prepare complex ─B(OH)2 moiety containing molecules in large numbers.