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. Author manuscript; available in PMC: 2019 Jul 5.
Published in final edited form as: Mol Cancer Ther. 2018 Nov 26;18(2):376–388. doi: 10.1158/1535-7163.MCT-17-0857

Figure 6.

Figure 6.

Phospholipid and TG synthesis pathway. Phospholipids in cells can be synthesized via the CDP-DG and Kennedy pathway using PA and TG. Inhibitors against FASN and DGAT have an impact on both pathways. FASN inhibitor inhibits FA biosynthesis, whereas DGAT catalyzes the synthesis of TG from DG and Acyl-CoA. AGPAT, 1-acylglycerol-3-phosphate O-acyltransferase 1; CDS, cytidylyltransferase; CLS, Cardiolipin synthase; CPET, choline/ ethanolamine phophotransferase; CPT, choline phosphotransferase; GPAT1/3, glycerol-3-phosphate acyltransferase 1/3; PAP, phosphatidic acid phosphatase; PEMT, phosphatidylethanolamine N-methyltransferase; PGPS, phosphatidylglycerolphosphate synthase; PIS, phosphatidylinositol synthase; PSD1, phosphatidylserine decarboxylase; PSS, phosphatidylserine synthase.