Table 3.
Associations between quantities of investigated T cell populations and selected prognostic factors in breast cancers
| Intratumoral | Invasive edge stroma | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CD8 (n) | FOXP3 (n) | CD8/FOXP3 | CD8 (n) | FOXP3 (n) | CD8/FOXP3 | |||||||||||||
| Mean | SD | p | Mean | SD | p | Mean | SD | p | Mean | SD | p | Mean | SD | p | Mean | SD | p | |
| St Gallen 2015 molecular subtype | ||||||||||||||||||
| Luminal A | 106.1 | 102.4 | NS | 31.3 | 28.5 | < 0.005 | 4.62 | 3.52 | NS | 445.9 | 303.6 | < 0.001 | 127.0 | 110.8 | < 0.001 | 5.29 | 3.74 | NS |
| Luminal B | 141.1 | 105.1 | 69.9 | 70.3 | 3.79 | 3.36 | 723.2 | 406.4 | 252.2 | 140.9 | 3.89 | 3.28 | ||||||
| Luminal B/HER2+ | 133.4 | 82.1 | 64.7 | 52.7 | 2.81 | 1.57 | 829.5 | 493.6 | 237.7 | 175.3 | 4.39 | 2.30 | ||||||
| HER2+ non-luminal | 126.5 | 132.6 | 53.7 | 45.7 | 2.88 | 1.98 | 964.4 | 439.1 | 349.4 | 219.9 | 3.39 | 1.89 | ||||||
| TNBC | 234.6 | 257.0 | 70.0 | 55.1 | 3.39 | 2.36 | 919.5 | 480.2 | 275.0 | 173.1 | 3.92 | 1.83 | ||||||
| Histological grade | ||||||||||||||||||
| G1 | 62.3 | 34.7 | < 0.002 | 26.6 | 26.1 | < 0.001 | 2.95 | 1.31 | NS | 420.4 | 259.4 | < 0.001 | 112.7 | 83.2 | < 0.001 | 5.11 | 3.62 | NS |
| G2 | 119.5 | 107.1 | 43.0 | 41.2 | 4.69 | 3.96 | 571.9 | 367.9 | 176.9 | 129.8 | 4.63 | 3.32 | ||||||
| G3 | 193.2 | 200.5 | 68.7 | 56.2 | 3.25 | 2.12 | 941.7 | 465.5 | 307.5 | 194.0 | 3.85 | 2.20 | ||||||
| HER2 overexpression | ||||||||||||||||||
| No | 159.6 | 183.1 | NS | 53.0 | 52.1 | NS | 4.00 | 3.12 | NS | 671.1 | 445.2 | < 0.010 | 205.7 | 157.1 | < 0.008 | 4.52 | 3.10 | NS |
| Yes | 129.2 | 114.2 | 58.0 | 48.0 | 2.85 | 1.81 | 913.8 | 457.2 | 307.5 | 208.7 | 3.77 | 2.08 | ||||||
Kruskal–Wallis test was performed
NS not significant, n cell number counted