Table 4.

Associations between the percentage of analyzed cells in stromal lymphocytic infiltrates at the invasive margin and selected prognostic factors in breast cancer

	CD8 (%)			FOXP3 (%)			GATA3 (%)			CD8/FOXP3			CD8/GATA3			FOXP3/GATA3			TILs (%)
	Mean	SD	p	Mean	SD	p	Mean	SD	p	Mean	SD	p	Mean	SD	p	Mean	SD	p	Mean	SD	p
St Gallen 2015 molecular subtype
Luminal A	33.2	11.8	NS	9.1	4.5	NS	52.5	11.5	NS	4.86	3.80	NS	0.64	0.21	NS	0.18	0.12	< 0.025	15.6	12.2	< 0.001
Luminal B	35.9	11.5		10.4	1.8		55.4	11.9		3.52	1.08		0.65	0.18		0.20	0.07		19.5	13.6
Luminal B/HER2+	43.8	26.6		11.0	5.2		49.0	15.1		4.93	4.82		0.93	0.48		0.24	0.13		33.6	23.9
HER2+ non-luminal	34.1	12.3		12.1	4.9		49.0	12.2		3.18	1.46		0.75	0.35		0.27	0.12		43.1	19.6
TNBC	32.8	11.0		10.2	2.6		45.4	16.0		3.46	1.70		0.89	0.74		0.28	0.22		35.3	17.8
Histological grade
G1	30.3	12.6	NS	8.3	4.9	< 0.015	50.8	14.5	NS	5.26	4.70	NS	0.61	0.23	NS	0.19	0.14	< 0.035	14.1	12.5	< 0.001
G2	34.1	11.9		10.5	4.5		52.6	11.7		3.77	2.14		0.66	0.22		0.20	0.10		19.5	12.3
G3	36.6	15.8		10.8	3.4		48.3	14.3		3.79	2.64		0.86	0.59		0.26	0.18		37.8	20.6
HER2 overexpression
No	33.6	11.4	NS	9.7	3.4	NS	50.5	13.8	NS	4.08	2.82	NS	0.73	0.49	NS	0.22	0.16	NS	23.6	17.2	< 0.001
Yes	37.8	19.2		11.7	4.9		49.0	13.2		3.84	3.21		0.82	0.41		0.26	0.13		39.6	21.4

Kruskal–Wallis test was performed

NS not significant, % cell percentage evaluated