Fig. 3.

UTUC is predominantly luminal. a Supervised consensus clustering and heatmap of mRNA expression data from WCM UTUC, BCM-MDA UTUC, and TCGA UCB metadataset. BASE47 classifier (UNC) genes are listed on the right. Assigned TCGA, MDACC, and UNC clusters are represented on top (color key, bottom right). WCM UTUC and BCM-MDA UTUC cluster with the luminal subtype (yellow vertical bars) by UNC criteria, luminal subtype by MDACC criteria (orange horizontal bars) and luminal-papillary subtype by TCGA classification (red horizontal bars). b Non-negative matrix factorization (NMF) of WCM UTUC, BCM-MDA UTUC, and TCGA UCB tumors segregates gene expression along three principal components: basal/squamous (purple), luminal/CIS-low (pink), and extracellular matrix/epithelial–mesenchymal transition (ECM/EMT) (green). WCM UTUC tumors represented as black dots and BCM-MDA tumors represented as dark gray dots cluster with the luminal/CIS-low component