Table 1.
Gene expression changes in colorectal carcinoma as compared to normal tissue in our cohort and similarly in 2 TCGA cohorts.
Gene Symbol | Our cohort | TCGA-Microarray | TCGA-RNAseq | |||||
---|---|---|---|---|---|---|---|---|
Mean | SEM | Mean | SEM | p adj* | Mean | SEM | p adj* | |
ABCB1 | 0.451 | 0.05 | 0.332 | 0.021 | <0.0001 | 0.447 | 0.026 | <0.0001 |
ABCC2 | 4.211 | 1.03 | 3.45 | 0.333 | <0.0005 | 16.625 | 1.69 | <0.0001 |
ABCG2 | 0.113 | 0.01 | 0.074 | 0.008 | <0.0001 | 0.05 | 0.005 | <0.0001 |
ALDH1A1 | 0.667 | 0.08 | 0.579 | 0.043 | <0.0001 | 0.574 | 0.044 | <0.0001 |
CD166 (ALCAM) | 1.722 | 0.12 | 1.89 | 0.086 | <0.0001 | 1.955 | 0.057 | <0.0001 |
CDKN1A | 0.592 | 0.04 | 0.584 | 0.023 | <0.0001 | 0.457 | 0.017 | <0.0001 |
INHBB | 1.599 | 0.23 | 4.217 | 0.533 | <0.0001 | 6.88 | 0.645 | <0.0001 |
*Comparison of CRC versus NT (Normal Tissues) was performed by Welch’s t-test and p values for TCGA data were corrected for multiple testing by Benjamini-Hochberg method (p.adjust function in R environment). SEM - Standard error of the mean.