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. 2019 Jul 5;9:9787. doi: 10.1038/s41598-019-46217-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of carnitine and lipid metabolism in IDH mutation gliomas. (A) Schematic of the β-oxidation pathway: the lipid metabolism pathway. (B) Carnitine was reduced in the IDH mutant glioma group (red bars). The vertical scale shows the absolute quantification (nmol/g). (C) Acyl-carnitine was reduced in the IDH mutant glioma group (red bars). (D) Fatty acids were not obviously elevated in the IDH mutant glioma group (red bars). In graphs C and D, the vertical scales showed the number of carbon atoms. The horizontal axis scale shows the number of double bonds. The vertical scale shows the relative quantification based on the internal standard. Red bars, IDH1^R132H glioma; blue bars, normal IDH1 glioma; N.D., not detected; error bar, standard error of mean. *P < 0.05.