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. 2019 Jul 5;9:9759. doi: 10.1038/s41598-019-46093-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mean papillae density (±s.e.m.) based on three counts of the same image by a single operator at one month (3a) and six months (3b) from baseline. The different participant numbers are due to participant drop-out. No significant differences in papillae density were observed at one or six months (Wilcoxon signed-rank test, p = 0.54 and 0.20, respectively). (c,d) Show data for papillae diameter and relative position at baseline and six months for nine individuals, (n = 10 measures per participant at each time point). Two-tailed paired t-test revealed no significant differences in diameter (p-value range 0.32–0.95) or papillae position (p-value range 0.15–0.94).