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. 2019 Jul 5;9:9731. doi: 10.1038/s41598-019-46282-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MiuA selectively inhibits binding of cofilin to F -actin. (a) MiuA inhibits binding of cofilin to F-actin (upper panel), while jasplakinolide does not (lower panel). F-actin was incubated with (a) cofilin, (b) gelsolin or (c) Arp2/3 complex & GST-VCA, together with MiuA or jasplakinolide (molar ratio 1:10). Binding of gelsolin (b) or Arp2/3 (c) to F-actin were not influenced by MiuA or jasplakinolide. The amount of F-actin binding protein in the total sample, supernatant and pellets was quantified. Representative images of protein bands and quantifications are shown. (Kruskal–Wallis test with Dunns test as post hoc, **P < 0.01 vs. control, n = 3).