Table 2.
Significant gene set enrichment (category “biological process”, Fisher’s exact test: < 0.01) based on differentially regulated genes by MiuA compared to jasplakinolide.
| GO, ID | Term | Annotated | Significant | Expected | Fisher |
|---|---|---|---|---|---|
| GO:0071456 | cellular response to hypoxia | 146 | 7 | 1,09 | 0,00011 |
| GO:0030509 | BMP signaling pathway | 90 | 7 | 0,67 | 0,00015 |
| GO:0030900 | forebrain development | 213 | 8 | 1,6 | 0,00018 |
| GO:0045446 | endothelial cell differentiation | 74 | 5 | 0,55 | 0,00022 |
| GO:0007568 | aging | 194 | 7 | 1,45 | 0,0006 |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 92 | 5 | 0,69 | 0,00061 |
| GO:0045666 | positive regulation of neuron differentiation | 202 | 7 | 1,51 | 0,00077 |
| GO:0043410 | positive regulation of MAPK cascade | 272 | 8 | 2,04 | 0,00094 |
| GO:0006935 | chemotaxis | 295 | 8 | 2,21 | 0,00158 |
| GO:0032496 | response to lipopolysaccharide | 177 | 6 | 1,33 | 0,00207 |
| GO:0002064 | epithelial cell development | 124 | 5 | 0,93 | 0,00233 |
| GO:0001558 | regulation of cell growth | 260 | 7 | 1,95 | 0,00325 |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 198 | 6 | 1,48 | 0,00361 |
| GO:0051051 | negative regulation of transport | 265 | 7 | 1,99 | 0,00361 |
| GO:0072593 | reactive oxygen species metabolic process | 149 | 7 | 1,12 | 0,00471 |
| GO:0051216 | cartilage development | 110 | 6 | 0,82 | 0,00545 |
| GO:0043405 | regulation of MAP kinase activity | 218 | 6 | 1,63 | 0,00576 |
| GO:0071560 | cellular response to transforming growth factor beta stimulus | 155 | 5 | 1,16 | 0,00604 |
| GO:0006979 | response to oxidative stress | 300 | 7 | 2,25 | 0,00706 |
| GO:0051155 | positive regulation of striated muscle cell differentiation | 31 | 5 | 0,23 | 0,00727 |
The GOs marked in bold are unique for the comparison MiuA vs. jasplakinolide and do not show up in MiuA or jasplakinolide vs. control.