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. 2019 Jul 5;9:9760. doi: 10.1038/s41598-019-46215-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of intra-NASh THC and selective MOR antagonists on place conditioning behaviors. (a) Anterior NASh (+2.5 mm from bregma) microinfusions of THC dose dependently increases preference for the drug paired side. Co-administration of cyprodime, but not Nor-BNI, dose-dependently blocks this effect. (b) Difference scores of the data presented in (a) showing the effect of THC in the anterior NASh. (c) In contrast, posterior NASh (+1.5 mm from bregma) THC dose dependently produces a conditioned place aversion. Co-administration of Nor-BNI, but not cyprodime, dose-dependently blocks this effect. (d) Difference scores of the data presented in (c) showing the effect of THC in the posterior NASh. (e) Infusions of the effective doses of cyprodime (1 μg) or Nor-BNI (1 μg) vs. VEH produce neither reward nor aversion effects in the CPP paradigm. (f) THC in the anterior (but not posterior) NASh (100 ng) selectively potentiates the rewarding effects of a sub-reward threshold CPP conditioning dose of morphine.