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. 2019 Jul 5;9:9760. doi: 10.1038/s41598-019-46215-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of ICV THC and nor-BNI on MSN activity patterns in the pNASh. (a) Representative microphotograph showing typical intra-pNASh in vivo MSN recording location. (b) Summary of experimental neuronal groups showing relative changes (no change, increase, or decrease) in firing frequencies following ICV pharmacological treatments. (c) ICV THC significantly increased spontaneous pNASh MSN neuronal firing frequency. (d) ICV THC alone (1 µg/μl) caused a significant increase in spontaneous aNASh MSN neuronal firing frequency rates vs baseline activity. This excitatory effect was reversed by co-administration of the behaviorally effective dose of nor-BNI (10 µg/μl). (e) Sample rastergram showing typical pNASh MSN response pattern following ICV THC (1 µg/µl) infusion (arrows indicate intra-NAc infusion event). (f) Sample rastergram showing typical aNASh MSN response pattern following ICV THC (1 µg/µl) and nor-BNI (10 µg/µl) infusion (arrows indicate intra-NAc infusion event).