Fig. 6.

c-Jun is elevated in Fbxw7 mutant nerves. Previously published RNAseq data²⁴ from WT sciatic nerves at P3 and P21 was mined to reveal that, in addition to Fbxw7 itself and mTOR, several other well-known targets of Fbxw7 are expressed during SC development (a). Immunofluorescence studies of control (b, c) and Dhh^cre(+);Fbxw7^fl/fl (d, e; white arrows indicate c-Jun positive nuclei; cKO) nerves at 6 months. cKO nerves display nearly three times the proportion of c-Jun + nuclei relative to controls (f; p = 0.0025 (**), unpaired t-test with Welch’s correction). N = 3 per genotype. Error bars depict S.D.