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. 2019 Jul 5;10:2976. doi: 10.1038/s41467-019-10881-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Fbxw7 orchestrates SC biology via mTOR-dependent and -independent mechanisms. Artistic renditions of the phenotypes observed in Fbxw7 mutant SCs (right) as compared with normal SCs (left). Fbxw7 is involved in radial sorting (top), as well as both mature myelinating SCs (middle) and Remak SCs (bottom). A simplified PI3K/mTOR pathway shows that in SCs, Fbxw7 directly inhibits mTOR, and thus regulates multiple aspects of SC biology. Fbxw7 may regulate SC myelinating potential through its control of c-Jun. Steps in the pathway that were not demonstrated directly in this study are shown in gray. Pencil sketches by B.L.H.