Table 2.
Patient characteristics of the CKD cohort.
| Cohort (N = 63) | Progressive (N = 24) | Stable (N = 39) | p-value | |
|---|---|---|---|---|
| Age [years] | ||||
| Min | 17.06 | 20.00 | 17.06 | |
| Max | 74.00 | 74.00 | 73.85 | |
| Mean (sd) | 47.22 ± 17.49 | 56.19 ± 13.90 | 41.70 ± 17.32 | 0.00057 |
| Creatinine [mg/dL] | ||||
| Min | 0.44 | 0.44 | 0.49 | |
| Max | 6.21 | 6.21 | 4.18 | |
| Mean (sd) | 1.55 ± 0.95 | 1.96 ± 1.13 | 1.31 ± 0.73 | 0.01624 |
| eGFR [ml/min/1.73 m2] | ||||
| Min | 9.46 | 9.46 | 16.24 | |
| Max | 153.68 | 153.68 | 150.58 | |
| Mean (sd) | 63.28 ± 35.20 | 49.54 ± 32.74 | 71.73 ± 34.36 | 0.01335 |
| UPCR [g/g] | ||||
| Min | 0.22 | 0.72 | 0.22 | |
| Max | 12.77 | 11.23 | 12.77 | |
| Mean (sd) | 4.36 ± 3.37 | 4.22 ± 2.80 | 4.45 ± 3.71 | 0.78860 |
| Follow-up time [years] | ||||
| Min | 0.52 | 0.52 | 1.22 | |
| Max | 17.08 | 11.34 | 17.08 | |
| Mean (sd) | 7.01 ± 4.30 | 4.7 ± 3.24 | 8.44 ± 4.28 | 0.00024 |
| Gender | ||||
| Female | 27 (43%) | 5 (21%) | 22 (56%) | |
| Male | 36 (57%) | 19 (79%) | 17 (44%) | 0.01418 |
| Medication at baseline [n (%)] | ||||
| RAAS blockade | 29 (46) | 13 (54) | 16 (41) | |
| Antidiabetics | 5 (8) | 3 (13) | 2 (5) | |
| Statins | 13 (21) | 6 (25) | 7 (18) | |
| Steroids | 12 (19) | 3 (13) | 9 (23) | |
| NSAIDs | 2 (3) | 0 (0) | 2 (5) | |
| NA | 10 (16) | 6 (25) | 4 (10) | 0.33380 |
| Histological diagnoses [n (%)] | ||||
| DN | 5 (8) | 5 (21) | 0 (0) | |
| FSGS | 7 (11) | 3 (13) | 4 (10) | |
| GN | 1 (2) | 1 (4) | 0 (0) | |
| HTN | 7 (11) | 4 (17) | 3 (8) | |
| IGAN | 4 (6) | 3 (13) | 1 (3) | |
| LN | 11 (17) | 1 (4) | 10 (26) | |
| MCD | 10 (16) | 0 (0) | 10 (26) | |
| MN | 10 (16) | 4 (17) | 6 (15) | |
| MPGN | 2 (3) | 2 (8) | 0 (0) | |
| VASC | 5 (8) | 1 (4) | 4 (10) | |
| Other | 1 (2) | 0 (0) | 1 (3) | 0.56460 |
Clinical parameters are given for the CKD cohort [n = 63] as well as for the subsets of patients with a stable [n = 39] and progressive [n = 24] course of disease. eGFR = estimated glomerular filtration rate; UPCR = urine protein to creatinine ratio; RAAS = renin angiotensin aldosterone system; NSAIDs = non-steroidal anti-inflammatory drugs; DN = diabetic nephropathy; FSGS = focal segmental glomerulosclerosis; GN = glomerulonephritis; HTN = hypertensive nephropathy; IGAN = IgA glomerulonephritis; LN = lupus nephritis; MCD = minimal change disease; MN = membranous nephropathy; MPGN = membranoproliferative glomerulonephritis; VASC = vasculitis.