Table 1.

Design of Candidate siRNAs-GalNAc Conjugates and Unconjugated Controls

Oligonucleotide	Sequence (5′ → 3′)	siRNA
5X-S	5′-CGCGGCGAGGAGCAA GGCGACUU-3′-X	Gal-5 (5Gal-S:5-AS)
5Gal-S	5′-CGCGGCGAGGAGCAA GGCGACUU-3′-GalNAc	CTRL-5 (5X-S:5-AS)
5-AS	5′-GUCGCCUUGCUCCU CGCCGCGUU-3′
p5X-S	5′-CCCUGUGGAGACUU GGGGGACUU-3′-X	Gal-p5 (p5Gal-S:p5-AS)
p5Gal-S	5′-CCCUGUGGAGACUU GGGGGACUU-3′-GalNAc	CTRL-p5 (p5X-S:p5-AS)
p5-AS	5′-GUCCCCCAAGUCU CCACAGGGUU-3′

S, sense; AS, antisense.