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. 2019 Jun 18;23:101905. doi: 10.1016/j.nicl.2019.101905

Fig. 2.

Fig. 2

Altered μOR of the right amygdala regarding type of migraine, attack severity, and thermal pain threshold. (A) Pie graph illustrating the relative percentages of variance (R2) explained by μOR BPND level in the right amygdala (MNI_[22,2,-16]), during the attack, in response to migraine type, P.A.I.N.S, and cutaneous thermal pain threshold (overall R2 = 71%). Amygdala μOR BPND is mostly affected by the type of migraine (partial-R2 = 47%) compared to P.A.I.N.S (partial-R2 = 16%) and thermal pain threshold sensitivity (partial-R2 = 8%). P.A.I.N.S and thermal pain threshold sensitivity were set at their mean value (85.47 and 43.04 respectively). (B–D) Scatterplot analysis of amygdala μOR BPND in response to each of the three variables shown in (A), adjusted for the other two. (B) Type of migraine: significant lower amygdala μOR BPND for CM vs. EM (P-value<0.001). (C) Attack severity: adjusted linear regression model indicating a significant negative linear correlation between P.A.I.N.S. and amygdala μOR BPND levels (P-value = 0.031). (D) Thermal pain threshold: adjusted linear regression model showing a marginal positive linear correlation between amygdala μOR BPND and cutaneous STPT (P-value = 0.1).