Table 4.
Mutational profiling of 19 patients with paired specimens
| Cases | Specimens | Mutationsa |
|---|---|---|
| Same mutation | ||
| Pair 01 | Skin, neck (Re) | NRAS p.Q61L |
| Lymph node, neck (Re) | NRAS p.Q61L | |
| Pair 02 | Skin, thigh (Re) | NRAS p.Q61R |
| Soft tissue, thigh (Re) | NRAS p.Q61R | |
| Pair 03 | Skin, upper arm (Bx) | NRAS p.Q61R |
| Kidney (FNA) | NRAS p.Q61R | |
| Pair 04 | Soft tissue, axillar (Re) | NRAS p.G13R |
| Lymph node, axillar (Bx) | NRAS p.G13R | |
| Pair 05 | Lymph node, neck (Re) | BRAF p.V600K |
| Lung (Re) | BRAF p.V600K | |
| Pair 06 | Soft tissue, upper arm (Re) | NRAS p.Q61R |
| Soft tissue, scalp (Bx) | NRAS p.Q61R | |
| Pair 07 | Lymph node, axillar (Re) | BRAF p.V600E |
| Soft tissue, chest (Re) | BRAF p.V600E | |
| Pair 08 | Lymph node, groin (Bx) | BRAF p.V600E |
| Lymph node, neck (FNA) | BRAF p.V600E | |
| Pair 09 | Skin, scalp (Bx) | No mutation |
| Lymph node, neck (FNA) | No mutation | |
| Pair 10 | Skin, thigh (Re) | NRAS p.Q61R |
| Lymph node, iliac (Bx) | NRAS p.Q61R | |
| Pair 11 | Soft tissue, axillar (Re) | NRAS p.Q61R |
| Lymph node, axillar (Re) | NRAS p.Q61R | |
| Pair 12 | Skin, lower leg (Re) | NRAS p.Q61L |
| Lymoh node, groin (Re) | NRAS p.Q61L | |
| Pair 13 | Skin, upper back (Bx) | BRAF p.V600E |
| Soft tissue, upper back (Bx) | BRAF p.V600E | |
| Pair 14 | Brain (Re) | NRAS p.Q61R |
| Lymph node, neck (Re) | NRAS p.Q61R | |
| Pair 15 | Skin, chest (Re) | No mutation |
| Lymph node, axillar (Bx) | No mutation | |
| Pair 16 | Skin, nose (Re) | KIT p.L576 |
| Liver (Bx) | KIT p.L576 | |
| Pair 17 | Lung (Re) | No mutation |
| Lung (Re) | No mutation | |
| Different mutations | ||
| Pair 18 | Left lower lip (Bx) | BRAF p.V600E |
| Lower lip (Bx) | No mutation | |
| Pair 19 | Skin, right vulva (Re) | No mutation |
| Skin, right vulva (Re) | KIT p.N655K | |
Bx: biopsy; FNA: fine needle aspiration; Re: resection or excision
aMutations in the BRAF, HRAS, KIT, KRAS, NRAS and PIK3CA genes