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. 2019 Jul 5;19:665. doi: 10.1186/s12885-019-5864-1

Table 6.

Coexisting BRAF and activating RAS or PIK3CA mutations

BRAF kinase activity	BRAF ^a	RAS or PIK3CA^a
Coexisting BRAF and RAS^b
Class-2 BRAF mutation	p.K601E (35%)	NRAS p.G13 N (34%)
Class-2 BRAF mutation	p.G464R (5.5%)	NRAS p.Q61R (55%)
Class-3 BRAF mutation	p.G466A (30%)	KRAS p.G12D (49%)
	p.G466 V (19%)	HRAS p.G13 N (26%)
	p.S467 L (26%)	NRAS p.Q61K (24%)
	p.D594N (47%)	NRAS p.G12S (42%)
	p.D594N (59%)	HRAS p.Q61K (46%)
Coexisting BRAF and PIK3CA^c
Class-1 BRAF mutation	p.V600E (11%)	PIK3CA p.545 K (7.5%)
Class-1 BRAF mutation	p.V600K (56%)	PIK3CA p.545 K (24%)
Class-3 BRAF mutation	p.G466E (17%)	PIK3CA p.545 K (3.1%)

^aPercentage in the parenthesis indicates mutant allele frequency

^bA case with BRAF p.V600E and HRAS p.Q25* was not included

^cIncluding only PIK3CA mutations affecting codons 542, 545 or 1047