Fig. 1.

Individual swimmer plots for each patient in the overall study population. Depicting progression-free survival (PFS) for PTEN cohort (blue), and PFS for PIK3CA/AKT cohort (red). Patients who discontinued MK-2206 due to toxicity are depicted with a (#), while patients who discontinued MK-2206 due to patient choice are depicted with a (*). Two patients who were enrolled on the PTEN loss cohort had PTEN expressions on the pre-treatment biopsy sample are depicted with a (&). A patient who had both PTEN loss and PIK3CA mutation is depicted with a (^). One patient who had partial response starting at 12 weeks (▲)