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. 2019 Jul 5;21:78. doi: 10.1186/s13058-019-1154-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Expression of PI3K/AKT/mTOR signaling pathway markers in paired baseline and on-treatment samples. a IRS score for pAKT S473, pS6 S235/236, pS6 S240/244, and Ki-67 in paired baseline and on-treatment samples. b Expression of PI3K/AKT/mTOR signaling pathway markers in the two patients who demonstrated clinical benefit. Upper panel, patient with partial response in PIK3CA cohort; bottom panel, patient with stable disease in PTEN cohort