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. 2019 Jul 5;20:246. doi: 10.1186/s12882-019-1435-6

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Group comparison based on component 3. The IC map of component 3 in the control group predominantly consisted of the PCC, precuneus, bilateral inferior parietal and MPFC (P < 0.001, AlphaSim corrected). Similar functional connectivity but with somewhat disrupted intrinsic connectivity in several DMN areas was found in the ESRD group (P < 0.001, AlphaSim corrected). The ESRD group showed significantly decreased connectivity in the PCC and the adjacent precuneus (P < 0.05, AlphaSim corrected, cluster size≥428 voxels) compared with the control group