Table 4.
Summary of imaging results across the 2 groups of ataxic patients (MSA-C, SAOA) and healthy control subjects. One-way ANOVA did not demonstrate a significant difference in Cho/Cr from the hemisphere, so post hoc testing was not preformed
| MSA-C | SAOA | MSA-C vs SAOA | Controls | MSA-C compared to controls | ||||
|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | P-value | Mean | SD | P-value | |
| Vermis NAA/Cr | 0.67 | 0.12 | 0.82 | .16 | P = 0.003‡ | 0.99 | 0.10 | P < 0.001+‡ |
| Vermis Cho/Cr | 0.62 | 0.25 | 0.76 | .18 | P > 0.05 | 0.80 | 0.08 | P = 0.040+ |
| Hemisphere NAA/Cr | 0.72 | 0.25 | 0.97 | .20 | P = 0.001‡ | 1.01 | 0.09 | P < 0.001+‡ |
| Hemisphere Cho/Cr | 0.70 | 0.21 | 0.82 | .22 | P > 0.05 | 0.78 | 0.12 | P > 0.05 |
| Brainstem volume (% of TICV) | 0.72 | 0.22 | 1.16 | .18 | P < 0.001‡ | 1.25 | 0.19 | P < 0.001+‡ |
| Cerebellum volume (% of TICV) | 5.64 | 0.60 | 4.97 | 1.12 | P > 0.05 | 7.53 | 1.15 | P < 0.001+‡ |
| Brainstem volume (cm3) | 10.86 | 3.33 | 17.02 | 2.49 | P < 0.001+‡ | 18.95 | 2.64 | P < 0.001+‡ |
| Cerebellum volume (cm3) | 82.17 | 8.16 | 72.87 | 16.29 | P = 0.078+ | 115.28 | 15.14 | P < 0.001‡ |
+ANOVA with Tukey’s HSD post hoc
‡remain statistically significant after Bonferoni correction