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. 2019 Jul 5;7:107. doi: 10.1186/s40478-019-0750-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — HDAC inhibition using ACY-738 restores transcriptional and proteomic alterations in spinal cord of Tg FUS+/+ mice. a Differentially expressed genes (DEGs) in vehicle- or ACY-738-treated Tg FUS+/+ mice compared to non-Tg controls. b Pearson correlation analysis on genes with completely restored expression after ACY-738 therapy. Correlation between expression values in vehicle-treated Tg FUS+/+ mice compared to non-Tg controls (x-axis) versus the expression values in ACY-738-treated compared to vehicle-treated Tg FUS+/+ mice (y-axis). c Differentially expressed proteins (DEPs) in vehicle- or ACY-738-treated Tg FUS+/+ mice compared to non-Tg controls. d Pearson correlation analysis on proteins with completely restored expression after ACY-738 therapy. Correlation between expression values in vehicle-treated Tg FUS+/+ mice compared to non-Tg controls (x-axis) versus the expression values in ACY-738-treated compared to vehicle-treated Tg FUS+/+ mice (y-axis). e Heatmap of –log₁₀ P-values of pathways that were significantly enriched after panther gene ontology (GO) analysis on differentially expressed genes/proteins in vehicle-treated Tg FUS+/+ mice compared to non-Tg controls, and in ACY-738-treated Tg FUS+/+ mice compared to vehicle-treated Tg FUS+/+ mice. RNA sequencing (R), proteomics (P)