Table 1.
The characteristics of included studies
| First author, year | Country | Ethnicity | Type of disease | Sample size | Genotypes (wtwt/wtmt/mtmt) | p value for HWE | NOS score | |
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | |||||||
| rs7903146 C/T | ||||||||
| Acharya 2015 | Saudi Arabia | South Asian | T2DM | 359/351 | 131/137/91 | 132/143/76 | 0.002 | 8 |
| Al-Sinani 2015 | Oman | South Asian | T2DM | 992/294 | NA | NA | NA | 7 |
| Anjum 2018 | China | East Asian | T2DM | 339/191 | 160/117/62 | 110/56/25 | < 0.001 | 7 |
| Assmann 2014 | Brazil | Mixed | T2DM | 953/535 | 382/415/156 | 261/215/59 | 0.147 | 8 |
| Barra 2012 | Brazil | Mixed | T2DM | 113/139 | 49/47/17 | 70/63/6 | 0.076 | 7 |
| Barros 2014 | Brazil | Mixed | T2DM | 108/109 | 53/49/6 | 58/40/11 | 0.304 | 7 |
| Beloso 2018 | Uruguay | Mixed | T2DM | 177/133 | 84/66/27 | 71/47/15 | 0.104 | 7 |
| Bielicki 2019 | Poland | Caucasian | T2DM | 121/479 | 69/45/7 | 285/172/22 | 0.539 | 7 |
| Bodhini 2007 | India | South Asian | T2DM | 1031/1038 | 462/455/114 | 555/391/92 | 0.055 | 8 |
| Cai 2019 | China | East Asian | T2DM | 296/446 | 197/83/16 | 287/147/12 | 0.180 | 8 |
| Cauchi 2006 | France | Caucasian | T2DM | 2367/2499 | 787/1149/431 | 1208/1060/231 | 0.944 | 8 |
| Chandak 2007 | India | South Asian | T2DM | 955/399 | 391/423/141 | 205/160/34 | 0.726 | 8 |
| Chang 2007 | Taiwan | East Asian | T2DM | 760/760 | NA | NA | NA | 7 |
| Chidambaram 2016 | India | South Asian | T2DM | 877/838 | NA | NA | NA | 7 |
| Corella 2016 | Spain | Caucasian | T2DM | 3411/3607 | 1158/1680/573 | 1612/1569/426 | 0.140 | 8 |
| Dahlgren 2017 | Sweden | Caucasian | T2DM | 168/885 | 67/83/18 | 496/327/62 | 0.421 | 8 |
| Danquah 2013 | Germany | Caucasian | T2DM | 674/375 | 273/323/78 | 182/165/28 | 0.257 | 7 |
| De Silva 2007 | UK | Caucasian | T2DM | 601/2099 | 211/299/91 | 1032/887/180 | 0.586 | 7 |
| El-Lebedy 2016 | Egypt | Caucasian | T2DM | 180/210 | 48/126/6 | 112/95/3 | < 0.001 | 8 |
| Erkoç Kaya 2017 | Turkey | Caucasian | T2DM | 171/120 | 58/95/18 | 57/47/16 | 0.215 | 7 |
| Ezzidi 2009 | Tunisia | Caucasian | T2DM | 863/511 | 250/396/217 | 181/235/95 | 0.227 | 8 |
| Groves 2006 | UK | Caucasian | T2DM | 2001/2476 | 771/960/270 | 1175/1084/217 | 0.139 | 8 |
| Guewo-Fokeng 2015 | Cameroon | African | T2DM | 74/74 | 37/30/7 | 37/37/0 | 0.004 | 7 |
| Gupta 2010 | India | South Asian | T2DM | 195/161 | 55/96/44 | 62/78/21 | 0.647 | 8 |
| Hayashi 2007 | Japan | East Asian | T2DM | 1619/1069 | 1450/165/4 | 980/85/2 | 0.146 | 8 |
| Horikoshi 2007 | Japan | East Asian | T2DM | 1174/823 | 1051/119/4 | 770/51/2 | 0.243 | 8 |
| Hsiao 2017 | Taiwan | East Asian | T2DM | 562/986 | 497/62/3 | 933/52/1 | 0.755 | 7 |
| Humphries 2016 | UK | Caucasian | T2DM | 1459/2493 | 601/665/193 | 1295/1001/197 | 0.854 | 7 |
| Humphries 2016 | UK | South Asian | T2DM | 837/300 | 366/375/96 | 163/111/26 | 0.260 | 7 |
| Humphries 2016 | UK | African | T2DM | 307/311 | 141/136/30 | 161/124/26 | 0.759 | 7 |
| Hussain 2014 | India | South Asian | T2DM | 123/82 | 45/63/15 | 43/35/4 | 0.350 | 7 |
| Isakova 2019 | Kyrgyzstan | Caucasian | T2DM | 114/109 | 91/20/3 | 89/16/4 | 0.009 | 8 |
| Jia 2016 | China | East Asian | T2DM | 248/267 | 125/73/50 | 165/74/28 | < 0.001 | 8 |
| Kalantari 2019 | Iran | South Asian | T2DM | 530/420 | 155/241/134 | 187/173/60 | 0.056 | 7 |
| Katsoulis 2018 | Greece | Caucasian | T2DM | 148/80 | 30/104/14 | 54/23/3 | 0.779 | 7 |
| Khan 2015 | India | South Asian | T2DM | 42/98 | 13/18/11 | 57/33/8 | 0.312 | 7 |
| Khan 2015 | India | South Asian | T2DM | 250/250 | 92/120/38 | 144/87/19 | 0.255 | 7 |
| Kimber 2007 | UK | Caucasian | T2DM | 3225/3291 | 1405/1459/361 | 1714/1329/248 | 0.663 | 8 |
| Kong 2015 | China | East Asian | T2DM | 5169/4560 | NA | NA | NA | 7 |
| Kunika 2008 | Japan | East Asian | T2DM | 1422/1423 | 1246/171/5 | 1309/111/3 | 0.689 | 8 |
| Löfvenborg 2019 | Sweden | Caucasian | T2DM | 1242/1530 | NA | NA | NA | 7 |
| Marquezine 2008 | Brazil | Mixed | T2DM | 285/1681 | 83/160/42 | 684/833/164 | < 0.001 | 8 |
| Mayans 2007 | Sweden | Caucasian | T2DM | 824/820 | 452/318/54 | 532/253/35 | 0.481 | 8 |
| Miranda-Lora 2017 | Mexico | Mixed | T2DM | 156/212 | 115/38/3 | 157/51/4 | 0.952 | 8 |
| Miyake 2008 | Japan | East Asian | T2DM | 2154/1834 | 1921/228/5 | 1696/137/1 | 0.295 | 8 |
| Moran 2015 | Venezuela | African | T2DM | 70/73 | 26/35/9 | 46/22/5 | 0.307 | 8 |
| Musavi 2015 | Iran | South Asian | T2DM | 70/100 | 19/36/15 | 45/48/7 | 0.222 | 7 |
| Ouhaibi-Djellouli 2014 | Algeria | African | T2DM | 76/644 | 16/41/19 | 228/287/129 | 0.027 | 8 |
| Palizban 2017 | Iran | South Asian | T2DM | 204/80 | 60/95/49 | 32/41/7 | 0.224 | 8 |
| Palmer 2011 | USA | Mixed | T2DM | 982/1039 | NA | NA | NA | 7 |
| Papandreou 2019 | Spain | Caucasian | T2DM | 869/244 | 382/383/104 | 106/103/35 | 0.225 | 8 |
| Plengvidhya 2018 | Thailand | East Asian | T2DM | 500/500 | 429/67/4 | 456/44/0 | 0.303 | 8 |
| Pourahmadi 2015 | Iran | South Asian | T2DM | 200/200 | 109/68/23 | 126/59/15 | 0.037 | 8 |
| Rees 2008 | UK | South Asian | T2DM | 828/432 | 352/360/116 | 222/166/44 | 0.122 | 8 |
| Reyes-López 2019 | Mexico | Mixed | T2DM | 23/83 | 14/6/3 | 59/24/0 | 0.124 | 7 |
| Saadi 2008 | United Arab Emirates | South Asian | T2DM | 180/188 | 56/103/21 | 71/94/23 | 0.339 | 7 |
| Scott 2006 | USA | Mixed | T2DM | 1151/953 | NA | NA | NA | 7 |
| Tabara 2009 | Japan | East Asian | T2DM | 481/398 | 434/45/2 | 372/26/0 | 0.501 | 8 |
| Turki 2013 | Tunisia | South Asian | T2DM | 895/878 | 255/432/208 | 330/414/134 | 0.824 | 7 |
| Uma Jyothi 2015 | India | South Asian | T2DM | 758/621 | 341/326/83 | 391/193/37 | 0.048 | 7 |
| van Vliet-Ostaptchouk 2007 | Netherlands | Caucasian | T2DM | 496/907 | 203/221/72 | 459/365/83 | 0.397 | 7 |
| Včelák 2012 | Czech Republic | Caucasian | T2DM | 347/376 | 148/156/43 | 205/147/24 | 0.731 | 8 |
| Wang 2013 | China | East Asian | T2DM | 1842/7777 | 1553/283/6 | 6718/1032/27 | 0.057 | 8 |
| Wrzosek 2019 | Poland | Caucasian | T2DM | 129/345 | 67/50/12 | 219/113/13 | 0.738 | 8 |
| Yako 2015 | South Africa | African | T2DM | 152/328 | 66/74/12 | 184/129/15 | 0.199 | 8 |
| Yu 2009 | USA | Mixed | T2DM | 686/305 | 355/271/60 | 170/111/24 | 0.330 | 8 |
| Zhang 2016 | China | East Asian | T2DM | 227/5284 | 200/24/3 | 4567/701/16 | 0.045 | 8 |
| Zheng 2012 | China | East Asian | T2DM | 227/152 | 202/24/1 | 139/13/0 | 0.582 | 8 |
| Zhu 2017 | China | East Asian | T2DM | 497/782 | 478/19/0 | 740/41/1 | 0.584 | 8 |
| Zhuang 2018 | China | East Asian | T2DM | 90/96 | 54/26/10 | 69/24/3 | 0.611 | 7 |
T2DM type 2 diabetes mellitus, wt Wild type, mt mutant type, HWE Hardy–Weinberg equilibrium, NOS Newcastle–ottawa scale, NA not available