Table 2-.
Significant pathways amongst the genes that were correlated to 18F-FDG kinetics parameters and tissue fraction. A pathway was considered significant if at least two of its’ genes were on the analyzed list and had EASE<0.l.
| Parameter | Group | Specific pathways |
|---|---|---|
| Tissue-specific uptake rate (Kis) | Metabolism | Fructose and mannose metabolism, Biosynthesis of antibiotics |
| Tissue specific volume of distribution (Fes) | Environmental information processing | PI3K-Akt signaling, Calcium signaling, NF-kappa B signaling, Jak-STAT signaling, TNF signaling, Cytokine-cytokine receptor interaction |
| Immune system | Toll-like receptor signaling, T cell receptor signaling, Natural killer cell mediated cytotoxicity, Antigen processing and presentation | |
| Phosphorylation rate (k3) | Excretory system | Aldosterone-regulated sodium reabsorption |
| Tissue fraction (FTIS) | Environmental information processing | Jak-STAT signaling, Neuroactive ligand-receptor interaction |
| Immune system | Toll-like receptor signaling, T cell receptor signaling, RIG-I-like receptor signaling, Hematopoietic cell lineage | |