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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: J Allergy Clin Immunol. 2019 Feb 16;144(1):183–192. doi: 10.1016/j.jaci.2019.01.045

Table 1. Summary of case basic demographics, clinical characteristics, HLA risk allele carriage and DRESS history.

Legend: ID, patient identification; Age, age at time of vancomycin treatment; Latency, days between vancomycin initiation and symptoms development; HLA, human leukocyte antigen; Trough, last vancomycin trough level before development of hypersensitivity symptoms in µg/mL. F, female; M, male; W, Caucasian; W/H, Caucasian/Hispanic; B, African American; N/A, not available; MRSA, Methicillin-resistant Staphylococcus aureus; MRSE, Methicillin-resistant Staphylococcus epidermidis; AML, acute myeloid leukemia; E. coli, Escherichia coli.

ID Age Sex Race Latency RegiSCAR Naranjo HLA-A*32: 01 Trough Indication for vancomycin Other implicated medications
1 56 F W 18 5 8 Positive 27 MRSA cervical spine post-operative wound infection rifampin
2 52 M W 26 6 8 Positive 9 Culture negative post-operative soft tissue infection of right foot ceftriaxone, ciprofloxacin
3 59 M W 19 4 8 Positive 14 Gram-positive cocci right chronic calcaneal osteomyelitis ciprofloxacin
4 66 M W 21 4 8 Positive 3 MRSA osteomyelitis rifampin
5 27 M W/H 29 5 8 Positive 21 Lumbar spine osteomyelitis isoniazid, rifampin,ethambutol pyrazinamide
6 33 M W 28 5 8 Positive 14 MRSE-infected mesh post bariatric surgery abdominal repai None
7 52 M W 17 6 8 Positive 16 Epidural abscess and osteomyelitis with Gram-positive bacteremia ceftriaxone
8 48 M B 21 5 8 Negative 12 Cellulitis post exploratory laparotomy and inguinal hernia repair piperacillin-tazobactam
9 53 F W 23 7 8 Positive 7 Culture negative soft tissue infection with underlying rib osteomyelitis levofloxacin, fluconazole
10 29 M W 26 5 8 Positive 19 Traumatic arm injury and possible osteomyelitis trimethoprim/sulfa methoxazole, piperacillin-tazobactam, ciprofloxacin
11 58 M W 36 6 8 Positive 22 Culture negative osteomyelitis ciprofloxacin
12 62 M W 21 4 8 Negative 21 Implantable cardioverter defibrillator pocket infection None
13 17 M W 29 4 8 Positive 10 MRSA bacteremia secondary to right pelvic myositis and phlebitis ibuprofen, hydroxyzine
14 51 F W 14 6 8 Positive 23 Enterococcus faecium bacteremia ceftazidime
15 57 M W 15 5 8 Negative 24 Culture negative febrile neutropenia and neutropenic colitis during AML treatment meropenem
16 24 F W 14 6 10 Positive 16 MRSE and Bacteroides fragilis post-operative wound infection following caesarean section and supracervical hysterectomy for uterine necrosis azithromycin, clindamycin, gentamicin, piperacillin-tazobactam, amoxicillin,meropenem, metronidazole
17 38 M W 18 5 8 Positive 14 MRSA right chest phlegmon, deep soft tissue infection, underlying osteomyelitis of 2nd rib with fracture rifampin
18 47 F W 17 6 8 Positive 13 MRSA and E. coli bacteremia w/ chest infiltrate levofloxacin
19 76 M W 27 6 8 Positive 12 Enterococcus bacteremia and endocarditis gentamicin, benzylpenicillin
20 61 F W 50 5 8 Positive N/A MRSA wound infection leading to hip prosthesis removal and placement of vancomycin spacer ciprofloxacin
21 71 F W 28 5 8 Negative 16 MRSA and E. coli hardware infection post knee replacement ceftriaxone, rifampin
22 40 F W 15 4 8 Positive 17 E. coli and Enterococcus faecalis urosepsis during pregnancy ceftriaxone
23 47 F W 15 5 8 Positive 22 Staphylococcus epidermis ventriculitis ceftriaxone