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. 2019 Mar 19;40(26):2164–2169. doi: 10.1093/eurheartj/ehz124

Figure 3.

Figure 3

Impact of prolonged mechanical unloading (PROPELLA approach) on cardiac mechano-transduction pathways in chronic inflammatory cardiomyopathy. (A) Graphs represent integrin mRNA expression, normalized to 18S with T1 set as 1 (α1: red, α5: grey, α6: blue, α10: black, and ß6: green) in EMB isolated during combined unloading and immune suppression (T1, T2), after Impella explantation (T3), and after Impella explantation and termination of immunosuppressive therapy (T4). Unloading combined with immunosuppressive therapy (T1, T2) decreases integrin expression. However, after explantation of the Impella, integrin expression increases again (T3), which is for α1, 5, 6, and ß6 also further pronounced after termination of immunosuppressive therapy (T4). The intensity distribution of (B) collagen alpha-2 (VI) (1215 Da) and (C) vimentin (1271 Da) is significantly decreased during combined unloading and immune suppression (T1, T2) compared with before unloading (T0). In contrast to integrin mRNA expression, this effect is further present post-explantation (T3) and termination of immunosuppressive therapy (T4).