Table 3:
Multivariable Association with Overall Survival
| Hazard Ratio (95% CI) |
HR p-value |
Type3 p-value |
||
|---|---|---|---|---|
| Surgery at Primary Site | Yes [n=5202 (44.5%)] | 0.82 (0.78–0.87) | <.001 | <.001 |
| No [n=6492 (55.5%)] | - | - | ||
| Age at Diagnosis | 1.01 (1.01–1.02) | <.001 | <.001 | |
| Race | Black | 1.14 (1.07–1.22) | <.001 | <.001 |
| Other/Unknown | 0.93 (0.83–1.05) | 0.260 | ||
| White | - | - | ||
| Charlson-Deyo Score | 2+ | 1.84 (1.66–2.03) | <.001 | <.001 |
| 1 | 1.27 (1.19–1.35) | <.001 | ||
| 0 | - | - | ||
| Facility Type | Community Cancer Program/Other | 1.24 (1.15–1.33) | <.001 | <.001 |
| Comprehensive Community Cancer Program | 1.14 (1.08–1.20) | <.001 | ||
| Integrated Network Cancer Program | 1.06 (0.97–1.16) | 0.179 | ||
| Academic/Research Program | - | - | ||
| Facility Location | Northeast | 0.98 (0.91–1.06) | 0.606 | 0.037 |
| South | 0.97 (0.91–1.05) | 0.482 | ||
| Midwest | 1.06 (0.98–1.14) | 0.146 | ||
| West | - | - | ||
| Primary Payor | Not Insured/Unknown | 1.20 (1.09–1.31) | <.001 | <.001 |
| Medicaid/Other Government | 1.27 (1.18–1.38) | <.001 | ||
| Medicare | 1.11 (1.04–1.19) | 0.002 | ||
| Private | - | - | ||
| Median Income Quartiles 2000 | < $30,000 | 1.14 (1.06–1.22) | <.001 | <.001 |
| $30,000 - $35,999 | 1.22 (1.14–1.30) | <.001 | ||
| $36,000 - $45,999 | 1.07 (1.01–1.13) | 0.024 | ||
| $46,000 + | - | - | ||
| Grade | Cell Type Not Determined | 1.30 (1.16–1.45) | <.001 | <.001 |
| Poorly Differentiated/ Undifferentiated | 1.36 (1.22–1.51) | <.001 | ||
| Moderately Differentiated | 1.12 (1.00–1.25) | 0.048 | ||
| Well Differentiated | - | - | ||
| Analytic T Stage | Unknown | 1.13 (1.01–1.25) | 0.028 | <.001 |
| T4 | 1.33 (1.20–1.47) | <.001 | ||
| T3 | 1.09 (0.97–1.24) | 0.151 | ||
| T2 | 1.04 (0.93–1.16) | 0.452 | ||
| T1 | - | - | ||
| Analytic N Stage | Unknown | 1.17 (1.10–1.26) | <.001 | <.001 |
| N3 | 1.07 (0.99–1.16) | 0.096 | ||
| N2 | 0.98 (0.89–1.08) | 0.728 | ||
| N1 | 0.98 (0.92–1.05) | 0.617 | ||
| N0 | - | - | ||
| ER | Negative | 1.31 (1.22–1.41) | <.001 | <.001 |
| Unknown | 1.18 (1.00–1.38) | 0.044 | ||
| Positive | - | - | ||
| PR | Negative | 1.32 (1.24–1.41) | <.001 | <.001 |
| Unknown | 1.12 (0.96–1.31) | 0.137 | ||
| Positive | - | - | ||
| Systemic Therapy | No | 2.05 (1.93–2.17) | <.001 | <.001 |
| Unknown | 0.93 (0.72–1.21) | 0.593 | ||
| Yes | - | - | ||
| Radiation Therapy at any CoC Facility | No | 1.19 (1.13–1.25) | <.001 | <.001 |
| Unknown | 0.63 (0.51–0.79) | <.001 | ||
| Yes | - | - | ||
*
Number of observations in the original data set = 16183. Number of observations used = 15544.
**
Backward selection with an alpha level of removal of .20 was used. The following variables were removed from the model: Percent No High School Degree Quartiles 2000, and Diagnosis Year (quartile).