Table 4:
Multivariable Association with Overall Survival Among Surgery Patients
| Covariate | Level | Hazard Ratio (95% CI) |
HR P- value |
Type3 P- value |
|---|---|---|---|---|
| Surgery | Mastectomy | 0.97 (0.90–1.05) | 0.450 | 0.450 |
| Breast Conserving Surgery | - | - | ||
| Age at Diagnosis | 1.01 (1.01–1.02) | <.001 | <.001 | |
| Race | African American | 1.11 (1.00–1.24) | 0.049 | 0.074 |
| Other/Unknown | 0.91 (0.75–1.10) | 0.320 | ||
| Caucasian | - | - | ||
| Charlson-Deyo Score | 2+ | 1.83 (1.53–2.18) | <.001 | <.001 |
| 1 | 1.24 (1.13–1.37) | <.001 | ||
| 0 | - | - | ||
| Facility Type | Community Cancer Program/Other | 1.31 (1.17–1.46) | <.001 | <.001 |
| Comprehensive Community Cancer Program | 1.15 (1.05–1.25) | 0.002 | ||
| Integrated Network Cancer Program | 1.12 (0.98–1.29) | 0.093 | ||
| Academic/Research Program | - | - | ||
| Facility Location | Northeast | 1.07 (0.95–1.21) | 0.268 | 0.114 |
| South | 1.09 (0.97–1.22) | 0.146 | ||
| Midwest | 1.15 (1.03–1.29) | 0.017 | ||
| West | - | - | ||
| Primary Payor | Not Insured/Unknown | 1.21 (1.03–1.42) | 0.021 | 0.007 |
| Medicaid/Other Government | 1.20 (1.06–1.37) | 0.005 | ||
| Medicare | 1.10 (0.99–1.22) | 0.076 | ||
| Private | - | - | ||
| Median Income Quartiles 2000 | < $30,000 | 1.08 (0.97–1.21) | 0.172 | <.001 |
| $30,000 - $35,999 | 1.30 (1.17–1.44) | <.001 | ||
| $36,000 - $45,999 | 1.13 (1.04–1.24) | 0.005 | ||
| $46,000 + | - | - | ||
| Grade | Cell Type Not Determined | 1.28 (1.06–1.55) | 0.010 | <.001 |
| Poorly Differentiated/Undifferentiated | 1.56 (1.33–1.82) | <.001 | ||
| Moderately Differentiated | 1.20 (1.02–1.40) | 0.025 | ||
| Well Differentiated | - | - | ||
| Analytic T Stage | Unknown | 1.07 (0.83–1.39) | 0.600 | <.001 |
| T4 | 1.37 (1.16–1.62) | <.001 | ||
| T3 | 1.09 (0.90–1.31) | 0.395 | ||
| T2 | 1.05 (0.89–1.25) | 0.557 | ||
| T1 | - | - | ||
| Analytic N Stage | Unknown | 1.34 (1.20–1.50) | <.001 | <.001 |
| N3 | 1.16 (1.03–1.29) | 0.011 | ||
| N2 | 1.02 (0.90–1.15) | 0.757 | ||
| N1 | 0.98 (0.89–1.09) | 0.757 | ||
| N0 | - | - | ||
| ER | Negative | 1.24 (1.10–1.40) | <.001 | 0.001 |
| Unknown | 1.25 (0.90–1.74) | 0.181 | ||
| Positive | - | - | ||
| PR | Negative | 1.30 (1.17–1.44) | <.001 | <.001 |
| Unknown | 1.08 (0.79–1.48) | 0.621 | ||
| Positive | - | - | ||
| Surgical Margins | Positive | 1.38 (1.27–1.50) | <.001 | <.001 |
| Unknown | 1.27 (1.09–1.48) | 0.003 | ||
| Negative | - | - | ||
| Chemotherapy at any CoC Facility | No | 1.30 (1.16–1.45) | <.001 | <.001 |
| Unknown | 0.94 (0.73–1.22) | 0.648 | ||
| Yes | - | - | ||
| Hormone Therapy at any CoC Facility | No | 1.29 (1.15–1.44) | <.001 | <.001 |
| Unknown | 0.74 (0.57–0.95) | 0.018 | ||
| Yes | - | - | ||
| Systemic Therapy | No | 1.22 (1.05–1.42) | 0.011 | 0.019 |
| Unknown | 1.54 (0.91–2.60) | 0.110 | ||
| Yes | - | - | ||
| Radiation Therapy at any CoC Facility | No | 1.24 (1.15–1.34) | <.001 | <.001 |
| Unknown | 0.75 (0.53–1.04) | 0.087 | ||
| Yes | - | - | ||
*
Number of observations in the original data set = 5201. Number of observations used = 4997.
**
Backward selection with an alpha level of removal of .20 was used. The following variables were removed from the model: Percent No High School Degree Quartiles 2000, and Diagnosis Year (quartile).