Figure 2.

Subcutaneous Adipose eQTL for PRKAR2A Colocalizes with the DALRD3 Adiponectin Exome-wide Locus

rs3087866 (purple diamond) shows the strongest association with adiponectin levels in the exome-wide meta-analysis (top plot). In the ADIPOGen genome-wide adiponectin meta-analysis (middle plot),¹⁴ rs3087866 and 85 proxy variants (r² > 0.80; 1000Gp3) are nominally associated with adiponectin levels. The same variants exhibit the strongest association with expression of PRKAR2A in subcutaneous adipose tissue (lower plot).⁴¹ Colocalized eQTL signals are also observed for AMT and NICN1 (see Figure S12). Each point represents a variant, plotted with hg19 genomic position on the x axis and p value (on a −log₁₀ scale) on the y axis. The color of all other variants indicates the LD with the lead variant in European ancestry haplotypes from the 1000 Genomes Phase 3 reference panel.