Table 1.

Adiponectin Loci in Sex-Combined and Sex-Specific Meta-analyses (Additive, adjBMI)

Variant	Chr	Position	Nearest Gene	Annotation	EA	EAF	Sex-Combined			Women			Men			Sex Diff.
							Effect	p	n	Effect	p	n	Effect	p	n	pa
Loci Achieving Exome-wide Significance
rs2276853	3	47,282,303	KIF9	missense (p.Arg638Gly)	A	0.594	−0.033	3.35E−08	65,521	−0.039	1.98E−06	31,788	−0.029	4.18E−04	33,733	4.17E−01
rs3087866	3	49,054,692	DALRD3	missense (p.Gln299Arg)	C	0.786	−0.040	2.14E−08	65,521	−0.034	5.88E−04	31,788	−0.046	3.67E−06	33,733	3.86E−01
rs13133548	4	89,740,128	FAM13A	intronic	A	0.489	−0.039	5.91E−12	65,521	−0.033	3.24E−05	31,788	−0.041	1.98E−07	33,733	4.61E−01
rs13107325	4	103,188,709	SLC39A8	missense (p.Ala391Thr)	T	0.047	0.072	1.05E−07	59,606	0.078	1.13E−05	31,788	0.050	1.25E−02	33,733	2.98E−01
rs10282707	7	17,911,038	SNX13	intronic	T	0.383	−0.040	1.96E−10	56,826	−0.024	1.07E−02	24,421	−0.053	3.44E−10	32,405	2.00E−02
rs3735080	7	150,217,309	GIMAP7	missense (p.Arg83Cys)	T	0.245	−0.049	7.70E−13	65,521	−0.036	2.72E−04	31,788	−0.057	6.22E−10	33,733	1.05E−01
rs11993554	8	145,111,529	OPLAH	synonymous (p.Phe612Phe)	G	0.101	0.030	3.75E−03	61,431	0.076	9.76E−08	29,427	−0.011	4.66E−01	32,004	2.52E−05
rs10861661	12	107,174,646	RIC8B	intronic	C	0.229	−0.040	1.75E−09	59,489	−0.035	4.74E−04	27,455	−0.046	3.17E−06	32,034	4.42E−01
rs145119400	16	84,075,593	SLC38A8	missense (p.Pro57Leu)	A	0.005	−0.300	8.95E−13	59,107	−0.306	1.78E−03	28,412	−0.296	1.80E−10	30,695	9.23E−01
Previously Reported Loci Achieving Exome-wide Significance
rs2791552	1	219,652,033	LYPLAL1	intergenic	C	0.676	0.676	1.75E−14	55,387	−0.055	8.97E−09	26,391	−0.054	7.16E−09	28,996	9.68E−01
rs2943641	2	227,093,745	IRS1	intergenic	C	0.646	0.646	1.76E−21	65,521	−0.048	2.21E−08	31,788	−0.069	2.56E−16	33,733	7.30E−02
rs13303	3	52,558,008	STAB1	missense (p.Met2506Thr)	C	0.569	0.569	2.69E−21	61,431	0.061	8.28E−13	29,427	0.060	4.74E−12	32,004	9.53E−01
rs17366568	3	186,570,453	ADIPOQ	ncRNA/exonic	A	0.118	0.118	1.43E−145	51,153	−0.216	1.61E−64	31,788	−0.239	5.86E−89	25,849	1.97E−01
rs4311394	5	53,300,662	ARL15	intronic	G	0.257	0.257	1.68E−10	59,931	−0.046	1.54E−06	28,914	−0.044	3.84E−06	31,017	9.13E−01
rs7134375	12	20,473,758	PDE3A	intergenic	A	0.410	0.410	3.69E−20	65,521	0.054	2.88E−11	31,788	0.053	5.36E−11	33,733	9.14E−01
rs11057405	12	122,781,897	CLIP1	intronic	A	0.086	0.086	2.90E−14	65,521	−0.092	1.74E−10	31,788	−0.068	1.24E−06	33,733	2.29E−01
rs11057353	12	124,265,687	DNAH10	missense (p.Ser167Pro)	C	0.645	0.645	2.74E−19	65,521	0.061	3.47E−13	31,788	0.047	2.19E−08	33,733	2.17E−01
rs2925979	16	81,534,790	CMIP	intronic	C	0.693	0.693	1.38E−37	61,801	0.093	6.72E−26	29,767	0.072	1.91E−16	32,034	8.80E−02
rs3865188	16	82,650,717	CDH13	intergenic	T	0.472	0.472	1.14E−08	59,420	−0.042	7.28E−07	28,616	−0.027	1.11E−03	30,804	2.27E−01
rs4805885	19	33,906,123	PEPD	intronic	C	0.603	0.603	2.85E−25	61,431	0.076	4.63E−19	29,427	0.052	5.77E−28	32,004	5.20E−02

Loci achieving exome-wide significance (p < 2E−07) in sex-combined and/or sex-specific all-ancestry meta-analyses. Beta effect size from an additive model corresponding to the effect allele for inverse-normal transformed adiponectin levels adjusted for age, BMI, and other study-specific covariates. The smallest p value for each variant is shown in bold. Physical positions based on hg19. Abbreviation: Chr, chromosome; EA, effect allele; EAF, effect allele frequency; n, sample size.

^aTest for sex difference; values significant at the table-wide Bonferroni threshold of 0.05/20 = 2.5E−03