Table 1.

Association Analyses between Individual SNPs and CRC Risk in the Discovery, Replication, and Combined Samples

SNP	Genotypes	Discovery Phase			Replication Phase			Combined Study
		Affected/controls	OR (95% CI)†	P value‡	Affected/controls	OR (95% CI)†	P Value‡	Affected/controls	OR (95% CI)†	P value‡
dbSNP: rs61926301	GG	538/649	1.00 (reference)		2,133/4,389	1.00 (reference)		2,671/5,038	1.00 (reference)
	GT	787/712	1.30 (1.12–1.52)	8.05 × 10−4	2,003/3,567	1.16 (1.08–1.25)	9.08 × 10−5	2,790/4,279	1.24 (1.16–1.32)	6.46 × 10−10
	TT	177/129	1.59 (1.23–2.06)	4.31 × 10−4	553/910	1.26 (1.12–1.42)	1.26 × 10−4	730/1,039	1.33 (1.19–1.48)	1.63 × 10−7
	Dominant		1.35 (1.16–1.56)	9.06 × 10−5		1.18 (1.10–1.27)	4.01 × 10−6		1.25 (1.18–1.34)	3.33 × 10−12
	Recessive		1.37 (1.07–1.74)	1.12 × 10−2		1.17 (1.05–1.31)	5.29 × 10−3		1.20 (1.08–1.33)	4.29 × 10−4
	Additive		1.28 (1.14–1.43)	2.92 × 10−5		1.14 (1.08–1.20)	2.26 × 10−6		1.18 (1.13–1.24)	7.97 × 10−12
dbSNP: rs7959129	GG	505/630	1.00 (reference)		1,686/3,583	1.00 (reference)		2,191/4,213	1.00 (reference)
	GT	753/668	1.38 (1.18–1.63)	7.46 × 10−5	2,208/3,965	1.17 (1.08–1.27)	7.31 × 10−5	2,961/4,633	1.21 (1.13–1.30)	9.03 × 10−8
	TT	259/212	1.49 (1.19–1.85)	4.49 × 10−4	795/1,318	1.30 (1.17–1.45)	1.58 × 10−6	1,054/1,530	1.32 (1.20–1.46)	9.25 × 10−9
	Dominant		1.40 (1.20–1.63)	1.54 × 10−5		1.20 (1.12–1.30)	1.05 × 10−6		1.24 (1.16–1.32)	3.00 × 10−10
	Recessive		1.24 (1.01–1.51)	3.94 × 10−2		1.19 (1.08–1.31)	4.83 × 10−4		1.19 (1.09–1.30)	1.02 × 10−4
	Additive		1.25 (1.13–1.39)	3.28 × 10−5		1.15 (1.09–1.21)	1.72 × 10−7		1.16 (1.11–1.22)	1.17 × 10−10

Abbreviations are as follows: OR = odds ratio and CI = confidence interval.

^†The calculation of ORs and 95% CIs was conducted under assumption that variant alleles were risk alleles.

^‡All p values were calculated with an unconditional logistic regression model after adjusting for gender, age group, smoking status, and drinking status.