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Experimental Design and Time Points of Individual Analyses
A graph showing the breeding scheme to obtain severe SMA and HET mice on mixed50 background (upper left), ASO treatments (blue boxes), and individual analyses at the indicated time points P21 and 3 and 6 months (MO). s.c., subcutaneous; i.c.v., intracerebroventicular; CMAP, compound muscle action potential; MUNE, motor unit number estimation; NMJ, neuromuscular junction.
