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. 2019 Jun 13;105(1):108–121. doi: 10.1016/j.ajhg.2019.05.011

Figure 1.

Figure 1

Liver Biopsies from Proband 1 Show Non-specific Findings Consistent with Liver Damage

(A) H&E shows moderate macrovesicular steatosis (200× magnification).

(B) Trichrome stain shows bridging fibrosis (100× magnification).

(C) Numerous lipid droplets are present in hepatocytes (HV = 80.0 kV; 2,100× direct magnification).

(D) Glycogen contents are in the normal range and there are no visible abnormalities in the endoplasmic reticulum (HV = 80.0 kV; 11,000× direct magnification).

(E) The bile canaliculus (center) is normal. Electron dense material consistent with biliary material is seen in the hepatocellular cytoplasm surrounding the bile canaliculus (HV = 80.0 kV; 11,000× direct magnification).

(F) There are no abnormalities of mitochondria and peroxisomes are present (HV = 80.0 kV; 21,000× direct magnification).