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. Author manuscript; available in PMC: 2020 Nov 21.
Published in final edited form as: J Theor Biol. 2019 Jan 5;481:28–43. doi: 10.1016/j.jtbi.2019.01.005

Figure 12: No significant change in the concentration of s2 or c2 occurs over the timescale tc2 in the auxiliary reaction mechanism (47)–(48) when tc1 ≪ tc2 ≪ ts2 ≪ ts1.

Figure 12:

The thick black curve is the numerically-integrated solutions to the mass action equations (49a)–(49d). The dashed vertical line corresponds to tc2 Note that there is no significant increase in the concentration of the intermediate complex over the tc2 timescale. The constants (without units) used in the numerical simulation are: e10=1, s10=1000, e20=1, k1 = 1, k2 = 1, k3 = 1, k−3 = 1, k4 = 100 and k−1 = 1. Time has been mapped to the t∞ scale: t∞(t) = 1 — 1/ln[t + exp(1)], and c2 has been scaled its maximum value.