Table 4.
Effect of IOP on 3 Year Graft Success
| N | 3-yr Graft Success (99% CI) | Hazard Ratio (99% CI) | P value | |
|---|---|---|---|---|
| History of glaucoma/ Postoperative Abnormal IOP at least 1 month following DSAEK | N=1277 | 0.28 | ||
| No/No | 927 | 97.9% (96.1%, 98.9%) | 1.00 | |
| Yes/No | 55 | 98.1% (78.2%, 99.9%) | 0.77 (0.05, 11.66) | |
| No/Yes | 239 | 95.8% (90.2%, 98.2%) | 1.81 (0.60, 5.47) | |
| Yes/Yes | 56 | 91.8% (73.3%, 97.7%) | 2.59 (0.50, 13.41) | |
| Early Acute IOP Event | N=1330 | 0.008 | ||
| No | 1306 | 94.1% (92.1%, 95.6%) | 1.00 | |
| Yes | 24 | 75.0% (43.8%, 90.5%) | 3.42 (1.01, 11.53) | |
IOP = intraocular pressure; DSAEK = Descemet stripping automated endothelial keratoplasty
Base model adjusted for PT, recipient diagnosis, donor history of diabetes, operative complications, and surgeon effects
History of glaucoma defined as had glaucoma surgery, and/or on glaucoma medications
Postoperative abnormal IOP defined as had new glaucoma surgery, or put on new glaucoma meds without new glaucoma surgery, or had IOP > 25 m Hg without any new glaucoma surgery or medications. (Eyes failed or censored within 1 month following DSAEK were eliminated). New glaucoma surgery performed included: tube shunt only (5 eyes), trabeculectomy only (2 eyes), laser trabeculoplasty only (3 eyes), and all 3 procedures (1 eye) in 11 participants.
Early acute IOP defined as any occurrence of IOP>40 or paracentesis for pupillary block or angle closure in the first week post-operatively