Table 1.

Clinical and Laboratory Features of the Post-Burn Triad

Systemic Inflammatory Response	Stress Response	Hypermetabolism
tachycardia	tachycardia	tachycardia
tachypnea	Increased endogenous glucocorticoid production	Muscle wasting
Leukocytosis or leukopenia	Increased sympathetic drive leading to increased catecholamine production	Increased oxygen consumption
hyperglycemia	Increased lipolysis and fatty acid oxidation	Insulin resistance
Increased C reactive Protein		Abnormal skeletal muscle mitochondrial function leading to uncoupling of mitochondrial respiration and heat production
thrombocytopenia		Browning of white adipose tissue
Coagulation disorders

Modified from Herndon DN Editor, Total Burn Care, Edinburgh, London, Elsevier, Fifth Edition 2018.