Table 3.
Outcomes of Aortic Valve Replacement According to the Delirium Status and Severity*
| Delirium severity | Prolonged Hospitalization | Institutional Discharge | Poor Functional Recovery or Death at 6 Month |
|||
|---|---|---|---|---|---|---|
| n / N (%) | OR (95% CI)† | n / N (%) | OR (95% CI)† | n / N (%) | OR (95% CI)b | |
| SAVR | 23 / 77 (29.9) | 41 / 75 (54.7) | 25 / 68 (36.8) | |||
| No delirium | 7 / 38 (18.4) | Reference | 16 / 38 (42.1) | Reference | 9 / 30 (30.0) | Reference |
| Mild delirium | 8 / 26 (30.8) | 2.1 (0.63, 7.4) | 14 / 24 (58.3) | 1.4 (0.40, 5.0) | 11 / 25 (44.0) | 1.5 (0.5, 5.1) |
| Severe delirium | 8 / 13 (61.5) | 7.1 (1.7, 30.3) | 11 / 13 (84.6) | 14.4 (2.0, 105.7) | 5 / 13 (38.5) | 1.2 (0.3, 5.0) |
| P-for-trend | P=0.009 | P=0.01 | P=0.72 | |||
| CAM-S score (per point) | 1.19 (1.01,1.39) | 1.24 (1.04,1.48) | 1.22 (0.91,1.63) | |||
| TAVR | 38 / 110 (34.6) | 47 / 108 (43.5) | 52 / 100 (52.0) | |||
| No delirium | 22 / 82 (26.8) | Reference | 26 / 80 (32.5) | Reference | 34 / 73 (46.6) | Reference |
| Mild delirium | 5 / 13 (38.5) | 1.8 (0.52, 6.4) | 9 / 13 (69.2) | 5.3 (1.4, 19.9) | 6 / 12 (50.0) | 1.1 (0.3, 3.9) |
| Severe delirium | 11 / 15 (73.3) | 7.7 (2.2, 27.4) | 12 / 15 (80.0) | 9.6 (2.3, 39.9) | 12 / 15 (80.0) | 4.7 (1.2, 18.4) |
| P-for-trend | P=0.001 | P<0.001 | P=0.03 | |||
| CAM-S score (per point) | 1.22 (1.08,1.40) | 1.37 (1.17,1.61) | 1.22 (1.07,1.39) | |||
Abbreviations: CI, confidence interval; OR, odds ratio; SAVR, surgical aortic valve replacement; TAVR, transcatheter aortic valve replacement
*
Delirium severity was defined as mild if CAM-S maximum score ≤9 and severe if CAM-S maximum score >9 (A CAM-S maximum score of 9 was the median CAM-S maximum score of patients with delirium).
†
Adjusted for age, sex, and Charlson Comorbidity Index.