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. 2019 Apr 14;27(7):1313–1326. doi: 10.1016/j.ymthe.2019.04.009

Figure 1.

Figure 1

Design and Characterization of AAV7m8 Vectors

(A) Outline of vector expression cassettes. Quantification of (B) Rheb mRNA and (C) AKT3 mRNA expression following transduction of 84-31 cells compared to untreated controls. Data represented as mean ± SD (n = 3). ****p < 0.0001. (D) Representative fundus image of mouse retina following subretinal delivery of AAV7m8.eGFP (2 × 109 vg). (E) Retinal tropism of AAV7m8 following subretinal injection. PN45 Pde6brd10 retinal flatmounts stained with antibodies directed against AKT that were untreated (F) and co-injected with AAV.AKT3 (1 × 109 vg) (G) and AAV.eGFP (1 × 109 vg) (H).