Figure 4.

Effect of AKT3 Gene Transfer on Retinal and Visual Function in the Pde6b^rd10 Retina

(A) Evaluation of mixed rod-cone a-wave amplitudes between untreated, AAV.eGFP, and AAV.AKT3-treated retina. (B) Assessment of mixed rod-cone b-wave amplitudes between treatments. (C) Photopic (cone) b-wave amplitudes between treatment groups. (D) Right/left eye ratio of visual acuity examined by optokinetic response (OKR). Right eyes were treated with AAV7m8.eGFP alone (2 × 10⁹ vg) or in combination with AAV.AKT3 while left eyes were untreated. (E) Representative mixed rod-cone ERG traces at PN30 and PN45 in a rd10 mouse treated with AAV.AKT3 in one eye and its contralateral untreated eye. Data represent mean ± SEM. *p < 0.05; ***p < 0.001. Index indicated by numerical values within bars.