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. 2019 Apr 14;27(7):1313–1326. doi: 10.1016/j.ymthe.2019.04.009

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AKT3-Induced Neuroprotection Is Associated with mTOR Activation

(A) Representative image of Rd10 retina treated with AAV.AKT3/AAV.eGFP and stained with antibodies directed against the mTORC2 activation marker, phospho-AKT^Ser473 (pink). (B) Co-localization with eGFP marking the region of subretinal delivery. (C) Higher magnification of AAV.AKT3/AAV.eGFP transduced section stained with mTORC2 marker. (D) Pde6b^rd10 retina treated with AAV.eGFP alone and stained with the mTORC2 marker. (E) Representative image of a Pde6b^rd10 retina treated with AAV.AKT3/AAV.eGFP and stained for the canonical mTORC1 activation marker, phospho-S6^Ser240/244 (pink). (F) Co-localization with eGFP. (G) Higher magnification of AAV.AKT3/AAV.eGFP transduced section stained with mTORC1 marker. (H) Pde6b^rd10 retina treated with AAV.eGFP alone and stained with the mTORC1 marker.