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. 2019 Apr 14;27(7):1313–1326. doi: 10.1016/j.ymthe.2019.04.009

Figure 6.

Figure 6

AKT3 Overexpression Does Not Breach Photoreceptor Quiescence but Activates Müller Cells

Representative micrograph of an untreated Pde6brd10 retinal cross-section stained with antibodies directed against GFAP (A), Ki67 (B), and co-localization of these markers with the addition of DAPI to identify retinal cell layers (C). Representative image of an Rd10 mouse retina treated with AAV7m8.eGFP (2 × 109 vg) alone and stained with antibodies directed against GFAP (D), Ki67 (E), and co-localization of these markers with the addition of DAPI to designate retinal cell layers and eGFP to identify transduced cell types (F). Representative micrograph of an Rd10 retina co-injected with AAV7m8.eGFP (1 × 109 vg) and AAV7m8.AKT3 (1 × 109 vg) stained with antibodies directed against GFAP (G), Ki67 (H), and co-localization of these markers with DAPI and eGFP (I).