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. 2019 Apr 14;27(7):1313–1326. doi: 10.1016/j.ymthe.2019.04.009

Figure 8.

Figure 8

Photoreceptor-Specific Expression of AKT3 Mediates Neuroprotection in the Pde6brd10 Retina

(A) Outline of vector expression cassettes. The AKT3 transgene is regulated by the photoreceptor-specific GRK1 promoter. Quantification of ERG responses for the (B) mixed a-wave, (C) mixed b-wave, and (D) cone b-wave between treatment groups. (E) Representative cross-section of a PN45 Pde6brd10 treated with AAV7m8.GRK1.AKT3 (1 × 109 vg). Photoreceptor-specific expression of AKT3 labeled with AKT antibodies (red). (F) Quantification of ONL thickness at PN45 between treatment groups. Data represented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.