Table 1.

The association between T‐cell immunosenescence composite scores and absolute numbers of p16INK4a positivity in human skin

	Epidermal p16INK4a positivity		Dermal p16INK4a positivity
	β (SE)	p‐value	β (SE)	p‐value
All subjects (N = 80)
CD4+ composite
Model 1	0.029 (0.030)	0.343	0.086 (0.036)	0.022
Model 2	0.002 (0.032)	0.956	0.093 (0.041)	0.025
CD8+ composite
Model 1	0.027 (0.028)	0.342	0.019 (0.036)	0.600
Model 2	0.014 (0.028)	0.608	0.031 (0.036)	0.400
CMV‐negative (N = 40)
CD4+ composite
Model 1	0.029 (0.030)	0.343	0.086 (0.036)	0.022
Model 2	0.028 (0.031)	0.385	0.093 (0.037)	0.017
CD8+ composite
Model 1	0.027 (0.028)	0.342	0.019 (0.036)	0.600
Model 2	0.014 (0.030)	0.644	0.039 (0.038)	0.310
CMV‐positive (N = 40)
CD4+ composite
Model 1	0.003 (0.046)	0.956	0.097 (0.064)	0.138
Model 2	−0.013 (0.046)	0.788	0.058 (0.067)	0.393
CD8+ composite
Model 1	0.045 (0.043)	0.304	0.032 (0.063)	0.611
Model 2	0.027 (0.041)	0.507	−0.027 (0.059)	0.651

Linear regression, data are given as β (standard error).

Model 1: crude model. Model 2: as model 1 plus adjustment for age, gender, and sunbed use. Composite scores: Z‐scores of CD45RA− CCR7− CD28− CD27−, CD57+, and KLRG1+, divided by 3.