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. 2019 Mar 21;42(7):zsz079. doi: 10.1093/sleep/zsz079

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Published by Oxford University Press on behalf of Sleep Research Society (SRS) 2019.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 2. — Altered Ferritin profile in L1CAM + nEVs in RLS. (A, B) People with RLS with the highest ferritin concentration and Control participants with the lowest ferritin concentrations were selected. Western blot (WB) image shows heavy-chain ferritin (FTH), light-chain ferritin (FTL), and Alix, a common nEV marker used for normalization. Normalized FTH was higher (** depicts p = 0.009) in people with RLS compared with Controls; there were no differences in FTL (ns refers to p = 0.17). (C, D) People with RLS and Controls with equivalent ferritin concentrations were selected. Normalized FTH was again higher (* depicts p = 0.04) in people with RLS compared with Controls; again there were no differences for FTL (ns refers to p = 0.45). Graphs depict mean ± SEM.