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. 2019 Jun 11;18(4):e12989. doi: 10.1111/acel.12989

Figure 6.

Figure 6

Overexpressed Rutabaga reversed Akt‐induced early death and Aβ42‐induced Akt activation and learning deficit. (a) Overexpressed Rutabaga in neurons reduced Akt‐induced early death in the elav>Akt flies. N = 100–170. There was significance between elav>Akt and elav>Akt+ Rut. p < 0.0001. Log‐rank analysis. (b) Rutabaga overexpression in neurons reversed Aβ42‐induced learning deficit in the 7‐ to 8‐day‐old elav>Aβ42 flies. N = 6 for each genotype. *p < 0.05. (c) Western blot showed Rutabaga overexpression in neurons reduced Aβ42‐induced Akt phosphorylation in the 7‐ to 8‐day‐old elav>Aβ42 flies. Bottom, the quantitative results showed that the Western blot band intensity of pAkt in elav>Aβ42 + Rut flies was less than in elav>Aβ42 flies. N = 9–14. *p < 0.05. This experiment was done at 25°C without heat induction. (d) Aging promotes Akt activation, which induces behavior damage and activates APP processing to promote Alzheimer's disease formation