Table 1.
Demographics
| Protocol | 12-C-0112 | 14-C-0059 | 14-C-0168 | 15-C-0029 | 16-C-0054 | 17-C-0048 | Total |
|---|---|---|---|---|---|---|---|
| CART type | CD19, CD28 | GD2, CD28, O × 40 | BCMA, CD28 | CD22, 41BB | CD19, CD28 | CD30, CD28 | – |
| Age group | pediatric + adult | pediatric + adult | adult | pediatric + adult | adult | adult | – |
| Diagnosis | ALL, DLBCL | osteosarcoma, neuroblastoma | multiple myeloma | ALL, DLBCL | ALL, DLBCL, MCL, FL, BL |
Hodgkin’s lymphoma | – |
| Infusion, n (%) | 56 (38.1) | 12 (8.2) | 20 (13.6) | 37 (25.2) | 20 (13.6) | 2 (1.4) | 147 (100) |
| Age (years) (mean ± SD) | 14.3 (±6.7) | 17.8 (±5.9) | 56.7 (±4.9) | 18.3 (±7.0) | 56.4 (±11.5) | 35.4(±8.9) | 27.7 (±19.9) |
| Male:female | 45:11 | 10:2 | 10:10 | 25:12 | 14:6 | 2:0 | 106:41 |
| Weight (kg) (mean ± SD) | 46.5 (±20.9) | 60.5 (±21.4) | 89 (±25.7) | 52.6 (±17.8) | 80.3 (±16.4) | 115 (±27.6) | 60.7 (±26.3) |
| CAR-T cell dose (million/kg) (mean ± SD) | 1.2 (±0.6) | 2.9 (±3.9) | 5.4 (±3.8) | 1.1 (±0.7) | 2.5 (±2.1) | 0.3 | 2.0 (±2.5) |
| Delivery vector | gamma-retrovirus | gamma-retrovirus | gamma-retrovirus | lentivirus | lentivirus | lentivirus | – |
| Pre-culture lymphocyte enrichment (n) | elutriation (5), bead enriched (46), both(5) | elutriation (5), bead enriched (7), both (0) | Ficoll (20) | elutriation (7), bead enriched (15), both (13), none (2) | Ficoll (20) | Ficoll (2) | – |
ALL, acute lymphoblastic leukemia; DLBCL, diffuse large B cell lymphoma; MCL, mantle cell lymphoma; FL, follicular lymphoma; BL, Burkitt’s lymphoma.