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Table 1.

Demographics

Protocol 12-C-0112 14-C-0059 14-C-0168 15-C-0029 16-C-0054 17-C-0048 Total
CART type CD19, CD28 GD2, CD28, O × 40 BCMA, CD28 CD22, 41BB CD19, CD28 CD30, CD28
Age group pediatric + adult pediatric + adult adult pediatric + adult adult adult
Diagnosis ALL, DLBCL osteosarcoma, neuroblastoma multiple myeloma ALL, DLBCL ALL, DLBCL,
MCL, FL, BL
Hodgkin’s lymphoma
Infusion, n (%) 56 (38.1) 12 (8.2) 20 (13.6) 37 (25.2) 20 (13.6) 2 (1.4) 147 (100)
Age (years) (mean ± SD) 14.3 (±6.7) 17.8 (±5.9) 56.7 (±4.9) 18.3 (±7.0) 56.4 (±11.5) 35.4(±8.9) 27.7 (±19.9)
Male:female 45:11 10:2 10:10 25:12 14:6 2:0 106:41
Weight (kg) (mean ± SD) 46.5 (±20.9) 60.5 (±21.4) 89 (±25.7) 52.6 (±17.8) 80.3 (±16.4) 115 (±27.6) 60.7 (±26.3)
CAR-T cell dose (million/kg) (mean ± SD) 1.2 (±0.6) 2.9 (±3.9) 5.4 (±3.8) 1.1 (±0.7) 2.5 (±2.1) 0.3 2.0 (±2.5)
Delivery vector gamma-retrovirus gamma-retrovirus gamma-retrovirus lentivirus lentivirus lentivirus
Pre-culture lymphocyte enrichment (n) elutriation (5), bead enriched (46), both(5) elutriation (5), bead enriched (7), both (0) Ficoll (20) elutriation (7), bead enriched (15), both (13), none (2) Ficoll (20) Ficoll (2)

ALL, acute lymphoblastic leukemia; DLBCL, diffuse large B cell lymphoma; MCL, mantle cell lymphoma; FL, follicular lymphoma; BL, Burkitt’s lymphoma.