Table 3.
Top 20 enriched genesets for biological process and function along with their associated adjusted P-values obtained from Enrichr (Chen et al., 2013)
| GO biological process | Adjusted P-value | GO molecular function | Adjusted P-value |
|---|---|---|---|
| Neutrophil mediated immunity | 3.03E−12 | MHC Class II receptor activity | 7.67E−03 |
| Neutrophil activation involved in immune response | 3.03E−12 | Activin binding | 7.67E−03 |
| Neutrophil degranulation | 4.62E−12 | MHC Class II protein complex binding | 7.67E−03 |
| Interferon-gamma-mediated signaling pathway | 4.62E−12 | MHC protein complex binding | 7.67E−03 |
| Cytokine-mediated signaling pathway | 9.91E−11 | Transforming growth factor beta binding | 7.67E−03 |
| Cellular response to interferon-gamma | 5.79E−10 | Phosphotyrosine residue binding | 7.67E−03 |
| Negative regulation of amyloid precursor protein catabolic process | 7.71E−05 | Transforming growth factor beta receptor binding | 7.67E−03 |
| Regulation of amyloid-beta formation | 7.94E−05 | Amyloid-beta binding | 7.67E−03 |
| Positive regulation of intracellular signal transduction | 1.62E−04 | Scavenger receptor activity | 1.04E−02 |
| Positive regulation of actin nucleation | 1.68E−04 | Protein phosphorylated amino acid binding | 1.09E−02 |
| Endocytosis | 2.26E−04 | Low-density lipoprotein receptor activity | 1.42E−02 |
| Regulation of mast cell degranulation | 3.07E−04 | Phosphatidylinositol bisphosphate binding | 1.42E−02 |
| Regulation of apoptotic process | 3.07E−04 | Protein kinase binding | 1.42E−02 |
| Extracellular matrix organization | 3.07E−04 | Clathrin heavy chain binding | 1.91E−02 |
| Negative regulation of amyloid-beta formation | 4.01E−04 | Lipoprotein particle receptor activity | 1.95E−02 |
| Antigen receptor-mediated signaling pathway | 4.01E−04 | GTPase regulator activity | 2.02E−02 |
| Negative regulation of extrinsic apoptotic signaling pathway | 5.26E−04 | Actin binding | 2.23E−02 |
| Regulation of amyloid-beta clearance | 5.77E−04 | Type II transforming growth factor beta receptor binding | 2.30E−02 |
| T cell receptor signaling pathway | 5.77E−04 | Low-density lipoprotein particle binding | 2.30E−02 |
| Cellular response to transforming growth factor beta stimulus | 1.09E−03 | Peptidase activity, acting on L-amino acid peptides | 2.30E−02 |