Table 3. .
Factors Associated With FIB-4 in HIV-Infected Persons (n = 101), With and Without Adjustment for Kyn/Trp Ratio
| Adjusted Modela | Adjusted Model With Kyn/Trp Ratiob | |||
|---|---|---|---|---|
| Variables | % Effect (95% CI) | P Value | % Effect (95% CI) | P Value |
| Age (per 10 y) | 43 (22 to 68) | <.001 | 37 (17 to 61) | <.001 |
| HIV/HCV coinfection | 68 (26 to 124) | <.001 | 52 (14 to 104) | .005 |
| CD4 count | –5.6 (–9.8 to –1.1) | .016 | –4.5 (–8.8 to 0) | .050 |
| Kyn/trp ratio | N/A | N/A | 29 (4 to 59) | .020 |
Abbreviations: CI, confidence interval; FIB-4, fibrosis-4 score; HCV, hepatitis C virus; IDU, injection drug use; kyn/trp ratio, kynurenine:tryptophan ratio; VAT, visceral adipose tissue.
aAdjusted for age, race, alcohol, marijuana, IDU, steatosis, VAT, and HIV viral load, in addition to the factors listed above.
bAdjusted for kyn/trp ratio, plus all factors in the previous model.